| Electrophysiological effects of intravenous prostacyclin in man. | |
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MedLine Citation:
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PMID: 6397357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The electrophysiological effects of prostacyclin (PGI2) were studied in 10 normal patients. Programmed stimulation was performed before and after infusion of 2.5, 5, 10 ng kg-1 min-1 of PGI2. Then, 0.2 mg kg-1 of propranolol was added to the higher dose of PGI2. We observed a net decrease of the systolic and diastolic arterial blood pressure beginning with the lowest dose. There was no effect on sinus node recovery time, atrial, His-Purkinje and ventricular effective refractory periods, AH and HV intervals. Atrioventricular (AV) nodal effective and functional refractory periods could be measured in 5 patients and were decreased in all cases. Sinus cycle length and anterograde and retrograde Wenckebach cycle lengths were significantly decreased by PGI2 in a dose dependent manner. The injection of propranolol increased all these values but did not suppress entirely the effects of PGI2. In conclusion, the electrophysiological effects of PGI2 were marked decreases of sinus cycle length and AV nodal refractoriness which may be partly related to enhanced sympathetic activity. |
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Authors:
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B Perrot; J P Clozel; A T de la Chaise; F Cherrier; G Faivre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 5 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-04-26 Completed Date: 1985-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 883-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrioventricular Node / drug effects Blood Pressure / drug effects Drug Synergism Electrophysiology Epoprostenol / pharmacology* Female Heart Atria / drug effects Humans Male Middle Aged Propranolol / pharmacology Sinoatrial Node / drug effects |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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