Document Detail

Electrophysiological effects of ethmozin on sinus nodal function in patients with and without sinus node dysfunction.
MedLine Citation:
PMID:  6373266     Owner:  NLM     Status:  MEDLINE    
The electrophysiological effects of intravenously administered ethmozin (1 mg kg-1) on sinus node function were examined in 32 patients. Based on their clinical data and the results of the initial study, patients were subdivided into group A (n = 12), those with sick sinus syndrome and sinus node recovery time (SNRT) greater than 1500 ms, and group B (n = 20), those without overt sinus node dysfunction and a normal SNRT. The mean sinus cycle length did not change significantly in either group after ethmozin . SNRT was prolonged by ethmozin in group A whereas in group B the increase of SNRT was not significant. Corrected SNRT increased after ethmozin in both subgroups but with a much more pronounced increase in group A. Sinoatrial conduction time was not significantly changed in any group. The lengthening of SNRT in the majority of patients with sick sinus syndrome implies that ethmozin might prolong post-tachycardia pauses in these patients. This drug should therefore be administered cautiously to persons with signs indicative of dysfunction of the sinus node.
P Rakovec; J Jakopin; P Rode; M F Kenda; M Horvat
Related Documents :
6493446 - Effect of vertebral, carotid and intravenous infusions of lysine vasopressin on plasma ...
698876 - Transient unilateral blindness following general anaesthesia: case report.
22157566 - Evidence for improvement in survival with antihypertensive combination treatment.
21943946 - Hypotension is 100 mm hg on the battlefield.
2415046 - Blood pressure distribution of nigerians in the first two decades of life.
19986 - The effect of hyoscine and atropine on the lower oesophageal sphincter.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  5     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-27     Completed Date:  1984-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Arrhythmia Agents*
Arrhythmias, Cardiac / drug therapy*,  physiopathology
Cardiac Pacing, Artificial
Infusions, Parenteral
Middle Aged
Phenothiazines / pharmacology*
Sick Sinus Syndrome / drug therapy*,  physiopathology
Sinoatrial Node / drug effects*,  physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Phenothiazines; 31883-05-3/Moricizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute myocardial infarction in renal transplant recipients: incidence and prognosis.
Next Document:  First degree atrioventricular block.