| Electrophysiological effects, efficacy and safety of intravenous propafenone in termination of atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia: a prospective non-randomized interventional study. | |
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MedLine Citation:
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PMID: 20635581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this prospective, non-randomized interventional study was to assess electrophysiological effects, efficacy and safety of intravenous propafenone in termination of atrioventricular nodal reentrant tachycardia (AVNRT) and orthodromic atrioventricular reentrant tachycardia (AVRT). This single-center study was carried out at Department of Cardiology, Sestre milosrdnice University Hospital in Zagreb, Croatia, between January 1, 2005 and December 31, 2006. Eligibility requirements were fulfilled by a total of 70 patients with AVNRT (n=37) and AVRT (n=33). The intervention consisted of the electrophysiological study aimed at inducing tachycardia, followed by intravenous administration of 2 mg/kg propafenone in both groups. The main outcome measures were safety and efficacy of 2 mg/kg intravenous propafenone in tachycardia termination and re-induction. Out of 37 patients with AVNRT, propafenone managed to terminate it in 28 (75.7%) patients, while tachycardia was not inducible in 25 (67.56%) patients. Out of 33 patients with AVRT, propafenone managed to terminate AVRT in 29 (87.9%) patients, while tachycardia was not inducible in 22 (66.66%) patients. The overall propafenone efficacy in tachycardia termination was 81.42%. No propafenone-related adverse effects were recorded during the study period. Propafenone was found to be a safe and effective anti-arrhythmic drug and can be justifiably administered for AVNRT and AVRT termination. It could be considered as an alternative to adenosine and verapamil. |
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Authors:
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Hrvoje Pintarić; Sime Manola; Janko Szavits Nossan; Nikola Pavlović; Diana Delić-Brkljacić; Vjekoslav Radeljić |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta clinica Croatica Volume: 49 ISSN: 0353-9466 ISO Abbreviation: Acta Clin Croat Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9425483 Medline TA: Acta Clin Croat Country: Croatia |
Other Details:
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Languages: eng Pagination: 25-31 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Department of Medicine, Sestre milosrdnice University Hospital, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Arrhythmia Agents / administration & dosage* Electrophysiologic Techniques, Cardiac Female Humans Infusions, Intravenous Injections, Intravenous Male Middle Aged Propafenone / administration & dosage* Tachycardia, Atrioventricular Nodal Reentry / drug therapy*, physiopathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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