| Electrophysiological effects of disopyramide in patients with bundle branch block. | |
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MedLine Citation:
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PMID: 758989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrophysiological studies were performed in 22 patients with intraventricular conduction delay before and after intravenous infusion of disopyramide (Norpace), 2 mg/kg. Mean control maximal sinus node recovery time (1039 +/- 187 msec), atrioventricular nodal conduction time (113 +/- 28 msec), and atrioventricular nodal effective refractory periods (349 +/- 67 msec) did not change significantly after administration of disopyramide (1073 +/- 284 msec, 112 +/- 31 msec, and 342 +/- 42 msec, respectively). Mean spontaneous cycle length (756 +/- 146 msec) decreased significantly 5 minutes after disopyramide (717 +/- 124 msec) (p less than 0.05), but not after 30 minutes (734 +/- 142 msec). A small but statistically significant (p less than 0.05) increase occurred after disopyramide in the mean atrial effective refractory period (259 +/- 51 to 280 +/- 53 msec), ventricular effective refractory period (253 +/- 23 to 275 +/- 33 msec), as well as the relative refractory period of the ventricular specialized conduction system (six patients) 433 +/- 78 to 479 +/- 62 msec). Although mean control infranodal conduction time (67 +/- 35 msec) increased 5 minutes after disopyramide (79 +/- 41 msec) (p less than 0.001) (18%), no spontaneous episodes of second-degree or third-degree atrioventricular block were observed. In six patients with premature ventricular depolarizations (greater than or equal to 1/min), the arrhythmia was totally abolished in four, markedly reduced in one, and remained unchanged in one. Disopyramide resulted in significant prolongation of infranodal conduction time as well as in atrial and ventricular refractoriness, but nevertheless appears to be safe in patients with bundle branch block. |
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Authors:
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J M Desai; M Scheinman; R W Peters; J O'Young |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 59 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 215-25 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrioventricular Node
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drug effects,
physiopathology Blood Pressure / drug effects Bundle of His / drug effects, physiopathology Bundle-Branch Block / drug therapy*, physiopathology Cardiac Pacing, Artificial Disopyramide / administration & dosage, adverse effects, therapeutic use* Drug Evaluation Electrocardiography Heart Conduction System / drug effects*, physiopathology Heart Rate / drug effects Humans Infusions, Parenteral Purkinje Fibers / drug effects, physiopathology Pyridines / therapeutic use* Sinoatrial Node / drug effects, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Pyridines; 3737-09-5/Disopyramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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