| Electrophysiological effects of carvedilol administration in patients with dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 18205033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Several studies suggest the clinical efficacy of carvedilol in reducing atrial and ventricular arrhythmias in patients with left ventricular dysfunction (LVD) due to congestive heart failure (CHF) or following myocardial infarction. However, the mechanisms supporting its antiarrhythmic efficacy have been derived from experimental studies. In this prospective, placebo-controlled trial we examined the electrophysiological effects of a high oral dose of carvedilol in patients with CHF and LVD due to non-ischemic dilated cardiomyopathy. METHODS: Thirty-one patients with stable CHF underwent electrophysiological study and were randomly assigned to treatment with carvedilol or placebo. After 2 months of treatment the study was repeated. RESULTS: Carvedilol prolonged almost all conduction times. In the same group atrial and ventricular effective refractory periods were significantly prolonged, while the parameters of repolarization remained virtually unchanged. The prolongation of refractoriness was most pronounced in the atrium. The change in ventricular refractoriness was correlated with ejection fraction (r = 0.94, p < 0.01) suggesting that patients with more preserved left ventricular function responded to treatment with greater prolongation. CONCLUSION: Even after a short period of administration carvedilol has marked and diffused electrophysiological effects that would be beneficial for patients with CHF and may contribute to the positive outcome of clinical trials. |
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Authors:
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Emmanuel M Kanoupakis; Emmanuel G Manios; Hercules E Mavrakis; Eleftherios M Kallergis; George M Lyrarakis; Emmanuel P Koutalas; Panos E Vardas |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-01-20 |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 22 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-11-03 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Affiliation:
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Cardiology Department, Heraklion University Hospital, Heraklion, Crete, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Adrenergic beta-Antagonists / therapeutic use* Aged Blood Pressure / drug effects Carbazoles / therapeutic use* Cardiomyopathy, Dilated / drug therapy*, physiopathology* Cardiotonic Agents / therapeutic use Death, Sudden, Cardiac / prevention & control Electrocardiography / drug effects Electrophysiology Female Humans Male Middle Aged Propanolamines / therapeutic use* Refractory Period, Electrophysiological / drug effects Risk Sinoatrial Node / drug effects Stroke Volume / drug effects, physiology Tachycardia, Ventricular / drug therapy, physiopathology Ventricular Function, Left / drug effects Ventricular Function, Right / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Cardiotonic Agents; 0/Propanolamines; 0K47UL67F2/carvedilol |
| Comments/Corrections | |
Comment In:
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Cardiovasc Drugs Ther. 2008 Jun;22(3):163-4
[PMID:
18392930
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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