| Electrophysiological effects of MS-551 in humans: a class III antiarrhythmic agent. | |
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MedLine Citation:
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PMID: 8552516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the clinical effects of MS-551, a Class III antiarrhythmic agent, 11 patients underwent electrophysiological study. MS-551 was given intravenously as an initial dose of 0.2 or 0.3 mg/kg for 5 minutes followed by the continuous infusion at 0.2 or 0.3 mg/kg for 30 minutes, respectively, in all patients. The rate corrected QT interval increased significantly from 3 minutes after the beginning of MS-551 infusion. The sinus heart rate decreased significantly by 8% at 10 minutes after the drug administration (P < 0.025). Mean PR and QRS intervals, and blood pressure were not significantly affected by the drug. Mean PA, AH, and HV intervals during sinus rhythm were also not affected. The effective refractory periods (ERPs) of the atrium and ventricle were significantly prolonged by 13% from 202 +/- 24 ms to 231 +/- 26 ms (P < 0.0005), and by 7% from 238 +/- 11 ms to 257 +/- 13 ms (P < 0.002), respectively, by MS-551. The ERP of the atrioventricular node and sinoatrial nodal recovery time were not changed significantly by the drug. This is a report of the effects of MS-551 in humans. This agent could be useful for treatment of tachyarrhythmias by prolongation of ERPs of the atrium and ventricle without significant variations of blood pressure and intracardiac conduction times. It is noteworthy that MS-551 slightly but significantly decreased heart rate. |
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Authors:
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S Isomoto; A Konoe; O A Centurion; M Hayano; M Kaibara; T Hirata; K Yano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 18 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-02-21 Completed Date: 1996-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2022-7 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Nagasaki University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Arrhythmia Agents / administration & dosage, blood, therapeutic use* Atrial Fibrillation / drug therapy*, physiopathology Atrioventricular Node / drug effects Blood Pressure / drug effects Bundle of His / drug effects Electrocardiography / drug effects Electrophysiology Female Heart Atria / drug effects Heart Rate / drug effects Heart Ventricles / drug effects Humans Infusions, Intravenous Injections, Intravenous Male Middle Aged Pyrimidinones / administration & dosage, blood, therapeutic use* Refractory Period, Electrophysiological / drug effects Sinoatrial Node / drug effects Tachycardia / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Pyrimidinones; 130656-51-8/MS 551 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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