Document Detail

Electrophysiological control of ventricular rate during atrial fibrillation.
MedLine Citation:
PMID:  10962745     Owner:  NLM     Status:  MEDLINE    
Thirteen anesthetized canine subjects (17-29 kg) were used to demonstrate that mild cervical left vagal stimulation could control ventricular rate effectively during atrial fibrillation (AF). Two studies are presented. The first study used six subjects to demonstrate the inverse relationship between (manually applied) left vagal stimulation and ventricular excitation (R wave) rate during AF. As left vagal stimulation frequency was increased, ventricular excitation rate decreased. In these studies, a left vagal stimulus frequency of 0-10 per second reduced the ventricular excitation rate from > 200/min to < 50/min. The decreasing ventricular excitation rate with increasing left vagal stimulation frequency was universal, occurring in all 26 trials with the six subjects. This fundamental principle was used to construct an automatic controller for use in the second study, in which seven subjects were used to demonstrate that ventricular rate can be brought to and maintained within a targeted range with the use of an automatic (closed-loop) controller. A 45-minute record of automatic ventricular rate control is presented. Similar records were obtained in all seven subjects.
M S Waninger; J D Bourland; L A Geddes; W E Schoenlein; G Graber; W E Weirich; G R Wodicka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  23     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1239-44     Citation Subset:  IM    
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47906, USA.
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MeSH Terms
Atrial Fibrillation / physiopathology*,  therapy
Blood Pressure / physiology
Electric Stimulation / methods*
Electric Stimulation Therapy
Equipment Design
Heart Rate*
Heart Ventricles / physiopathology
Vagus Nerve / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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