Document Detail

Electrophysiological characterization of cerebellar neurons from adult rats exposed to ethanol during development.
MedLine Citation:
PMID:  9726287     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the spontaneous activity of mature rat cerebellar neurons that had been exposed to ethanol (EtOH) during postnatal days 4 to 10, which corresponds to the third trimester in humans. Newborn Sprague-Dawley rats were implanted with gastric feeding tubes and were artificially reared from postnatal days 4 to 10 with two different diets. The experimental group received 4.5 g/kg/day of EtOH delivered in a milk solution. Controls received similar feeding with an isocaloric supplement replacing the EtOH. Electrophysiological evaluations were performed after an EtOH-free rearing period. Although lobules IX and X of the cerebellar vermis appeared morphologically smaller in the animals neonatally exposed to EtOH, compared with controls, extracellular recordings from both Purkinje cells and Golgi interneurons in adult rats showed no differences in spontaneous activity or firing pattern between the control and EtOH-exposed animals. Similarly, excitations and inhibitions of Purkinje neuron activity evoked by parallel pathway stimulation appeared unaffected by the developmental EtOH exposure. However, we did observe a significant decrease in the proportion of Purkinje neurons generating complex spike bursts in the group exposed to EtOH neonatally. These data suggest that, although fewer Purkinje neurons may survive the brain growth spurt if exposed to EtOH during this critical period of development, those that do survive appear to function normally. The observed abnormality in complex spike production may result from EtOH effects on developing neurons in the inferior olive that give rise to the climbing fibers that cause this bursting pattern in Purkinje neurons.
C Bäckman; J R West; J C Mahoney; M R Palmer
Related Documents :
14653177 - Role of the cerebellum in eyeblink conditioning.
2359497 - Long-term habituation of the acoustic startle response: role of the cerebellar vermis.
19358307 - Decreased gad65 mrna levels in select subpopulations of neurons in the cerebellar denta...
7325017 - Interaction of extracerebellar and cerebellar cortical inputs in dentate neurons of the...
7685067 - Spatially localized neuronal cell lineages in the developing mammalian forebrain.
9698327 - Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell d...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  22     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-15     Completed Date:  1998-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1137-45     Citation Subset:  IM    
Neuroscience Program, University of Colorado Health Sciences Center, Denver, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn
Cerebellum / drug effects*,  pathology,  physiopathology
Critical Period (Psychology)
Ethanol / toxicity*
Evoked Potentials / drug effects,  physiology
Fetal Alcohol Syndrome / pathology,  physiopathology*
Interneurons / drug effects,  pathology,  physiology
Purkinje Cells / drug effects,  physiology
Rats, Sprague-Dawley
Synaptic Transmission / drug effects*,  physiology
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of ethanol on recombinant glycine receptors expressed in mammalian cell lines.
Next Document:  Taste reactivity to alcohol and basic tastes in outbred mice.