| Electrophysiological brain activity and antisaccade performance in schizophrenia patients with first-rank (passivity) symptoms. | |
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MedLine Citation:
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PMID: 19906434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few studies have examined electrophysiological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS). In this study, we conducted a broad assessment of FRS patients' performance using data collected as part of the Western Australia Family Study of Schizophrenia, with a focus on event-related potential (ERP) measures [P50 suppression, mismatch negativity (MMN), the auditory oddball target (P300)], and the antisaccade task. A total of 39 patients (23 patients with, and 16 patients without FRS) and 80 controls were included. The results showed that patients with FRS had significantly reduced amplitude and longer latencies on the P300, as compared to controls. In addition, patients with FRS demonstrated more abnormalities on antisaccade error measures (error rate, self-correction latencies) relative to controls. On these measures, the performance of patients without FRS was not significantly different from controls. P300 and antisaccade error abnormalities in patients with FRS could not be accounted for by clinical variables, medication effects, or cognitive abilities. These results provide support for the proposal that FRS reflect a specific dysfunction in the monitoring and evaluation of sensory information. |
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Authors:
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Flavie Waters; Gregory Price; Milan Dragovi??; Assen Jablensky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-11 |
Journal Detail:
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Title: Psychiatry research Volume: 170 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 140-9 Citation Subset: IM |
Affiliation:
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Centre for Clinical Research in Neuropsychiatry, Perth 6910, Australia. Flavie@ccrn.uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Adult Brain / physiopathology* Brain Mapping Cognition Disorders / etiology* Contingent Negative Variation / physiology Electroencephalography / methods Evoked Potentials, Auditory / physiology Female Humans Male Middle Aged Neuropsychological Tests Psychiatric Status Rating Scales Psychomotor Performance / physiology Reaction Time / physiology Saccades / physiology* Schizophrenia / complications*, pathology* Schizophrenic Psychology* Verbal Learning / physiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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