Document Detail


Electrophysiological brain activity and antisaccade performance in schizophrenia patients with first-rank (passivity) symptoms.
MedLine Citation:
PMID:  19906434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Few studies have examined electrophysiological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS). In this study, we conducted a broad assessment of FRS patients' performance using data collected as part of the Western Australia Family Study of Schizophrenia, with a focus on event-related potential (ERP) measures [P50 suppression, mismatch negativity (MMN), the auditory oddball target (P300)], and the antisaccade task. A total of 39 patients (23 patients with, and 16 patients without FRS) and 80 controls were included. The results showed that patients with FRS had significantly reduced amplitude and longer latencies on the P300, as compared to controls. In addition, patients with FRS demonstrated more abnormalities on antisaccade error measures (error rate, self-correction latencies) relative to controls. On these measures, the performance of patients without FRS was not significantly different from controls. P300 and antisaccade error abnormalities in patients with FRS could not be accounted for by clinical variables, medication effects, or cognitive abilities. These results provide support for the proposal that FRS reflect a specific dysfunction in the monitoring and evaluation of sensory information.
Authors:
Flavie Waters; Gregory Price; Milan Dragovi??; Assen Jablensky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-11
Journal Detail:
Title:  Psychiatry research     Volume:  170     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  140-9     Citation Subset:  IM    
Affiliation:
Centre for Clinical Research in Neuropsychiatry, Perth 6910, Australia. Flavie@ccrn.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Adult
Brain / physiopathology*
Brain Mapping
Cognition Disorders / etiology*
Contingent Negative Variation / physiology
Electroencephalography / methods
Evoked Potentials, Auditory / physiology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales
Psychomotor Performance / physiology
Reaction Time / physiology
Saccades / physiology*
Schizophrenia / complications*,  pathology*
Schizophrenic Psychology*
Verbal Learning / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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