Document Detail


Electrophysiological remodeling in heart failure.
MedLine Citation:
PMID:  20096285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.
Authors:
Yanggan Wang; Joseph A Hill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-20
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  48     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-11-16     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-32     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Emory University, Atlanta, GA, USA. yanggan.wang@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisotropy
Arrhythmias, Cardiac / physiopathology
Atrioventricular Node / physiopathology
Electrophysiology / methods*
Gap Junctions
Heart / physiopathology
Heart Failure / physiopathology*
Humans
Myocardial Contraction
Myocardium / pathology
Potassium / chemistry
Purkinje Cells / metabolism
Rats
Grant Support
ID/Acronym/Agency:
HL-075173/HL/NHLBI NIH HHS; HL-080144/HL/NHLBI NIH HHS; HL-088168/HL/NHLBI NIH HHS; HL-090842/HL/NHLBI NIH HHS; HL083271/HL/NHLBI NIH HHS; P30 HL101254-01/HL/NHLBI NIH HHS; R01 HL075173-05/HL/NHLBI NIH HHS; R01 HL080144-04/HL/NHLBI NIH HHS; R01 HL090842-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7440-09-7/Potassium
Comments/Corrections

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