| Electrophysiological remodeling in heart failure. | |
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MedLine Citation:
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PMID: 20096285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure. |
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Authors:
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Yanggan Wang; Joseph A Hill |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-01-20 |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 48 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-11-16 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 619-32 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Emory University, Atlanta, GA, USA. yanggan.wang@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisotropy Arrhythmias, Cardiac / physiopathology Atrioventricular Node / physiopathology Electrophysiology / methods* Gap Junctions Heart / physiopathology Heart Failure / physiopathology* Humans Myocardial Contraction Myocardium / pathology Potassium / chemistry Purkinje Cells / metabolism Rats |
| Grant Support | |
ID/Acronym/Agency:
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HL-075173/HL/NHLBI NIH HHS; HL-080144/HL/NHLBI NIH HHS; HL-088168/HL/NHLBI NIH HHS; HL-090842/HL/NHLBI NIH HHS; HL083271/HL/NHLBI NIH HHS; P30 HL101254-01/HL/NHLBI NIH HHS; R01 HL075173-05/HL/NHLBI NIH HHS; R01 HL080144-04/HL/NHLBI NIH HHS; R01 HL090842-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-09-7/Potassium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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