Document Detail


Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium.
MedLine Citation:
PMID:  25015962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vagal nerve stimulation (VNS) has been proposed as a cardioprotective intervention. However, regional ventricular electrophysiological effects of VNS are not well characterized. The purpose of this study was to evaluate effects of right and left VNS on electrophysiological properties of the ventricles and hemodynamic parameters. In Yorkshire pigs, a 56-electrode sock was used for epicardial (n = 12) activation recovery interval (ARI) recordings and a 64-electrode catheter for endocardial (n = 9) ARI recordings at baseline and during VNS. Hemodynamic recordings were obtained using a conductance catheter. Right and left VNS decreased heart rate (84 ± 5 to 71 ± 5 beats/min and 84 ± 4 to 73 ± 5 beats/min), left ventricular pressure (89 ± 9 to 77 ± 9 mmHg and 91 ± 9 to 83 ± 9 mmHg), and dP/dtmax (1,660 ± 154 to 1,490 ± 160 mmHg/s and 1,595 ± 155 to 1,416 ± 134 mmHg/s) and prolonged ARI (327 ± 18 to 350 ± 23 ms and 327 ± 16 to 347 ± 21 ms, P < 0.05 vs. baseline for all parameters and P = not significant for right VNS vs. left VNS). No anterior-posterior-lateral regional differences in the prolongation of ARI during right or left VNS were found. However, endocardial ARI prolonged more than epicardial ARI, and apical ARI prolonged more than basal ARI during both right and left VNS. Changes in dP/dtmax showed the strongest correlation with ventricular ARI effects (R(2) = 0.81, P < 0.0001) than either heart rate (R(2) = 0.58, P < 0.01) or left ventricular pressure (R(2) = 0.52, P < 0.05). Therefore, right and left VNS have similar effects on ventricular ARI, in contrast to sympathetic stimulation, which shows regional differences. The decrease in inotropy correlates best with ventricular electrophysiological effects.
Authors:
Kentaro Yamakawa; Eileen L So; Pradeep S Rajendran; Jonathan D Hoang; Nupur Makkar; Aman Mahajan; Kalyanam Shivkumar; Marmar Vaseghi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-07-11
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  307     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-09-02     Completed Date:  2014-11-07     Revised Date:  2014-11-16    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H722-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 the American Physiological Society.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Blood Pressure
Endocardium / innervation,  physiology
Heart Rate
Pericardium / innervation,  physiology
Swine
Vagus Nerve / physiology*
Vagus Nerve Stimulation / adverse effects
Ventricular Function*
Grant Support
ID/Acronym/Agency:
R01 HL084261/HL/NHLBI NIH HHS; R01-HL-084261/HL/NHLBI NIH HHS; T32 GM008042/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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