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Electrophysiological Correlation and Prognostic Impact of Heat Shock Protein 27 in Atrial Fibrillation.
MedLine Citation:
PMID:  22354927     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -HSP27 is related to the pathogenesis of AF. However, the clinical relationship between HSP27 and AF is unclear. The present study was conducted to determine the clinical relationship between heat shock protein 27 (HSP27) and atrial fibrillation (AF). METHODS AND RESULTS: -A case-control study was conducted (AF, N=114; control, N=100). Serum HSP27 (HSP27S) levels were measured by ELISA, and its correlations with electrophysiological characteristics and catheter ablation outcomes were investigated. AF patients had a larger left atrial diameter (LAD), waist circumference, body mass index, and lower baseline HSP27S level than controls. After logistic multivariate analysis, low baseline HSP27S was independently associated with AF. In AF patients, those with paroxysmal AF (PAF) had higher baseline HSP27S levels compared to those with non-PAF. In PAF patients, lower baseline HSP27S was associated with larger LAD, while baseline HSP27S was not correlated with LAD in controls. In PAF, low baseline HSP27S (<3.85 ng/mL) was associated with low atrial voltage and non-pulmonary vein ectopies. In non-PAF, the mean fractionated interval had a good correlation with baseline HSP27S. After catheter ablation, a high baseline HSP27S level could predict sinus rhythm maintenance in the patients with PAF. Baseline HSP27S was also correlated with IL-10 and TNF-α levels. Analysis of buffy coat mRNA levels showed the same correlations. CONCLUSIONS: -HSP27S levels were correlated with LAD, left atrial voltage, and fractionated intervals, and predicted AF recurrence after catheter ablation. The mechanisms could be related to inflammation.
Authors:
Yu-Feng Hu; Hung-I Yeh; Hsuan-Ming Tsao; Ching-Tai Tai; Yenn-Jiang Lin; Shih-Lin Chang; Li-Wei Lo; Ta-Chuan Tuan; Kazuyoshi Suenari; Cheng-Hung Li; Tze-Fan Chao; Shih-Ann Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-21
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Taipei Veterans General Hospital & National Yang-Ming University, Taipei, Taiwan;
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