Document Detail


Electrophysiologic predictors of long-term clinical outcome with amiodarone for refractory ventricular tachycardia secondary to coronary artery disease.
MedLine Citation:
PMID:  3618488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-four patients with a previous myocardial infarction and drug-refractory symptomatic ventricular tachycardia (VT) were treated with amiodarone on a long-term basis (range 6 to 54 months, mean 26) irrespective of the results of programmed ventricular stimulation, which was performed after high-dose oral amiodarone loading for more than 4 weeks. VT was rendered noninducible in 6 of 54 patients (11%) taking oral amiodarone. During a mean follow-up of 32 months, these 6 patients remained free of VT or sudden cardiac death. Forty-eight patients (89%) continued to have VT inducible by programmed ventricular stimulation. However, they could be separated into 2 groups: VT-modified (20 patients) and VT-unchanged (28 patients). In the VT-modified group, the induced VT with amiodarone was slowed or rendered nonsustained, and only 3 of 20 (15%) patients during a mean follow-up of 23 months had well tolerated VT recurrences. In the VT-unchanged group, 16 of 28 patients (57%) had recurrences of VT or ventricular fibrillation during a mean follow-up of 24 months. Sudden cardiac death occurred in 6 of these 16 patients. Thus, programmed ventricular stimulation in patients with VT taking long-term amiodarone may have prognostic implications.
Authors:
Y Yazaki; C I Haffajee; R L Gold; R L Bishop; J S Alpert
Related Documents :
8552518 - Efficacy of antitachycardia pacing in patients presenting with cardiac arrest.
2297838 - Flunarizine allows differentiation between mechanisms of arrhythmias in the intact heart.
10803438 - The implantable cardioverter-defibrillator.
7616438 - Proarrhythmia of a class ic drug: suppression by combination with a drug prolonging rep...
23718858 - Deterioration of pre-existing hemiparesis due to injury of the ipsilateral anterior cor...
16164578 - Left ventricular function and calcium phosphate plasma levels in uraemic patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  60     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-08     Completed Date:  1987-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Amiodarone / therapeutic use*
Cardiac Pacing, Artificial
Female
Follow-Up Studies
Heart Conduction System / physiopathology*
Humans
Male
Middle Aged
Myocardial Infarction / complications*
Prognosis
Risk
Tachycardia / drug therapy*,  etiology
Time Factors
Ventricular Fibrillation / drug therapy*,  etiology
Chemical
Reg. No./Substance:
1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of the characteristics of nonsustained ventricular tachycardia on Holter monitoring and s...
Next Document:  31P nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with cong...