Document Detail

Electrophysiologic evaluation of antiarrhythmic drugs on supraventricular tachyarrhythmias.
MedLine Citation:
PMID:  6827776     Owner:  NLM     Status:  MEDLINE    
The effects of the intravenous administration of three drugs, i.e., verapamil, disopyramide, and procainamide, on paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation (Af) and atrial flutter (AF) were evaluated electrophysiologically. Efficacy on PSVT was 94.7% (36/38) with verapamil, 61.5% (13/18) with disopyramide and 100% (4/4) with procainamide. Efficacy on Af and AF was 9.1% (1/11) with verapamil and 80.0% (12/15) with disopyramide. PSVT termination mechanisms were as follows: 1) Verapamil: A-H block in 5 cases and H-A block in 5 cases with Type 1 A-V nodal reentrant tachycardia (AVNRT). H-A block in 6 cases with Type 2 and Type 3. A-H block in 17 of 18 cases with A-V reciprocating tachycardia (AVRT). Cycle length alternans were observed in 13 of 34 cases. 2) Disopyramide: H-A block in 2 cases with AVNRT and V-A block in 2 cases with AVRT. 3) Procainamide: V-A block in 4 cases with AVRT. These results suggest that verapamil and disopyramide are most effective on PSVT and Af, respectively.
K Hiejima; F Suzuki; M Takahashi; S Satake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  47     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  98-104     Citation Subset:  IM    
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / drug therapy
Atrial Flutter / drug therapy
Atrioventricular Node / physiopathology
Disopyramide / therapeutic use
Electric Stimulation
Procainamide / therapeutic use
Tachycardia / drug therapy*,  physiopathology
Tachycardia, Paroxysmal / drug therapy
Verapamil / therapeutic use
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 3737-09-5/Disopyramide; 51-06-9/Procainamide; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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