| Electrophysiologic effects of disopyramide in patients with atrioventricular nodal dysfunction. | |
| | |
MedLine Citation:
|
PMID: 7139899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Seventeen patients with first-degree or Mobitz I atrioventricular (AV) block and narrow QRS complexes underwent electrophysiologic drug testing before and after i.v. administration of disopyramide. Disopyramide did not significantly change the mean sinus cycle length (895 +/- 131 vs 877 +/- 119 msec), mean maximal sinus node recovery time (1134 +/- 160 vs 1133 +/- 13 msec), mean atrial effective refractory period (314 +/- 72 vs 307 +/- 54 msec), mean AV nodal conduction time (187 +/- 79 vs 180 +/- 73 msec) or the mean paced cycle length at which AV nodal Wenckebach conduction occurred (545 +/- 144 vs 497 +/- 130 msec) after disopyramide. The mean AV nodal effective refractory period decreased significantly (from 535 +/- 137 to 521 +/- 122 msec), and both infranodal conduction time and the paced ventricular cycle length producing ventriculoatrial block increased significantly (from 56 +/- 12 to 63 +/- 13 msec and from 625 +/- 158 to 655 +/- 157 msec, respectively). We conclude that i.v. disopyramide administered in a dose resulting in therapeutic blood levels showed no adverse effects on AV nodal conduction in patients with AV nodal dysfunction. In contrast, i.v. disopyramide depressed retrograde AV conduction. |
| | |
Authors:
|
P R Wilkinson; J Desai; J Hollister; R Gonzalez; J A Abbott; M M Scheinman |
Related Documents
:
|
7259829 - The hyperplastic muscle columns which encroach upon the branch mouths of the coronary a... 6640559 - Comparative study of electrophysiological and holter monitoring data in estimating sino... 4033449 - The effects of naloxone infusion and stellate ganglion blockade on hot flushes in the h... 6537039 - Qrs normalization of bundle branch block by ventricular fusion. 7681169 - Rapid resolution of new right bundle branch block in acute anterior myocardial infarcti... 1222879 - A histological survey of pre-excitation syndrome and related arrhythmias. 18474859 - Sildenafil and cardiomyocyte-specific cgmp signaling prevent cardiomyopathic changes as... 14559129 - Myocardial perfusion in real-time using power modulation. in vivo evidence for microcir... 7520789 - Expression of e-selectin on coronary endothelium after myocardial ischemia and reperfus... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Circulation Volume: 66 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1982 Dec |
Date Detail:
|
Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1211-6 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anti-Arrhythmia Agents / blood, therapeutic use Cardiac Pacing, Artificial Disopyramide / blood, therapeutic use* Electrocardiography Electrophysiology Heart Block / diagnosis, drug therapy*, physiopathology Humans Middle Aged Pyridines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 0/Pyridines; 3737-09-5/Disopyramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The incidence and clinical significance of epicardial late potentials in patients with recurrent sus...
Next Document: The cellular electrophysiologic mechanism of the dual actions of disopyramide on rabbit sinus node f...