| Electrophysiologic effects and clinical efficacy of oral propafenone therapy in patients with ventricular tachycardia. | |
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MedLine Citation:
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PMID: 3889099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the antiarrhythmic agent propafenone were evaluated in 25 patients with recurrent symptomatic ventricular tachycardia. Oral propafenone was given to a maximal dose of 300 mg every 8 hours. Ten of the 25 patients developed side effects or had inadequate suppression of spontaneous ventricular arrhythmias during propafenone therapy. Electrophysiologic studies were performed before and during drug therapy on the 15 patients who had a satisfactory clinical response. Propafenone increased the PR interval from 168 +/- 46 to 188 +/- 25 ms (p less than 0.007), the HV interval from 47 +/- 10 to 65 +/- 13 ms (p less than 0.005), the shortest atrial pacing cycle length to maintain 1:1 atrioventricular (AV) nodal conduction from 385 +/- 44 to 436 +/- 42 ms (p less than 0.005), the ventricular effective refractory period from 231 +/- 17 to 255 +/- 19 ms (p less than 0.001) and the ventricular functional refractory period from 260 +/- 15 to 278 +/- 17 ms (p less than 0.002). Before propafenone therapy, all 15 patients had ventricular tachycardia induced by programmed ventricular stimulation. During propafenone treatment, 12 patients still had ventricular tachycardia induced, and the tachycardia cycle length significantly increased from 236 +/- 44 to 374 +/- 103 ms (p less than 0.001). Ten patients were considered to have satisfactory electrophysiologic response to propafenone on the basis of either the inability to initiate ventricular tachycardia or a marked increase in ventricular tachycardia cycle length associated with lack of symptoms during the induced tachycardia. These patients were discharged receiving propafenone.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D A Chilson; J J Heger; D P Zipes; K F Browne; E N Prystowsky |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 5 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-10 Completed Date: 1985-07-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1407-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Anti-Arrhythmia Agents / administration & dosage, pharmacology, therapeutic use* Cardiac Pacing, Artificial Clinical Trials as Topic Electrophysiology Female Follow-Up Studies Heart Conduction System / drug effects* Heart Ventricles Humans Male Middle Aged Propafenone Propiophenones / administration & dosage, pharmacology, therapeutic use* Tachycardia / drug therapy*, etiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-06308/HL/NHLBI NIH HHS; HL-07182/HL/NHLBI NIH HHS; RR00750/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Propiophenones; 54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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