| Electrophysiologic correlates of steroid modulation of luteinizing hormone release. | |
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MedLine Citation:
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PMID: 7065175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In both ovariectomized (OVX) and steroid-primed OVX freely moving rats, attempts were made to correlate the effects of intraventricular norepinephrine (NE) on multiunit activity (MUA) of different brain regions with NE-induced alterations in blood LH levels. MUA-recording electrodes were implanted in the diagonal band of Broca (DBB), medial preoptic area (MPOA), arcuate nucleus (ARC) and/or ventromedial hypothalamic nucleus (VMH). Steroid priming included 50 micrograms estradiol benzoate (EB) and 25 mg progesterone (P) 3 days prior to experiment. The unanesthetized animals were bled via indwelling atrial cannulas before and after intraventricular infusion of NE (10 micrograms in 2 microliters over 2 min). In OVX-primed rats NE lengthened the interval between episodic LH peaks and decreased mean blood LH levels. In contrast, in OVX-EBP-primed rats, NE stimulated an LH surge. Concurrent recording of MUA revealed that, in OVX-unprimed rats, NE dramatically depressed MUA in both DBB-MPO and ARC-VMH neurons. However, in OVX-EBP-primed rats, while still markedly inhibiting ARC-VMH units, NE failed to depress MUA recorded in DBB-MPO sites (some units were actually excited by NE), perhaps reflecting the higher ratio of LHRH neurons/inhibitory neurons in DBB-MPO. |
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Authors:
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P C Leung; D I Whitmoyer; C H Sawyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 242 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E164-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Electrodes, Implanted Electrophysiology Female Frontal Lobe / physiology* Hypothalamus / physiology* Hypothalamus, Middle / physiology* Injections, Intraventricular Luteinizing Hormone / blood, secretion* Norepinephrine / pharmacology* Rats |
| Grant Support | |
ID/Acronym/Agency:
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NS-01162/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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