Document Detail


Electrophysiologic characteristics at initiation of ventricular tachycardia and ventricular fibrillation in a canine infarct model.
MedLine Citation:
PMID:  7522139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Local ventricular activation time and the conduction time during sinus rhythm at the induction of ventricular tachycardia (VT) and ventricular fibrillation (VF) were investigated using a canine model of chronic myocardial infarction. Of 26 dogs studied, 15 had inducible VT, 10 had inducible VF, and 1 had no inducible arrhythmias. Bipolar local ventricular electrograms were recorded during sinus rhythm from 136 sites in 10 dogs with VT and 164 sites in 11 dogs with VF. Mean activation time in dogs with inducible VT was significantly longer than in dogs with inducible VF. Furthermore, simultaneous local ventricular electrograms were recorded during the induction of VT (74 episodes) or VF (38 episodes) from the infarct border zone at the endocardium (B-EN), the epicardium (B-EP), and normal sites (N-EN, N-EP). During VT induction, the activation time at N-EN and N-EP was significantly longer than during VF induction (N-EN: 94 +/- 21, 70 +/- 19 ms; N-EP: 83 +/- 21, 64 +/- 10 ms; p < 0.05). Conduction time was measured at the initiation of VT or VF induced by orthodromic or antidromic pacing. The conduction times of the last paced beat between N-EN and B-EP (35 +/- 11, 62 +/- 24 ms), N-EN and N-EP (35 +/- 12, 14 +/- 13 ms), B-EN and B-EP (16 +/- 10, 38 +/- 25 ms), and B-EP and N-EP (77 +/- 27, 44 +/- 12 ms) were significantly different in dogs with inducible VT (p < 0.05), but not in dogs with VF.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K Moroe; A Coelho; R N Sampsell; Y H Chun; H N Mayrovitz; A J Gosselin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  17     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-10-14     Completed Date:  1994-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  384-90     Citation Subset:  IM    
Affiliation:
Miami Heart Institute, Miami Beach, Florida.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Complexes, Premature / physiopathology
Cardiac Pacing, Artificial
Dogs
Electrocardiography*
Endocardium / physiopathology
Heart Conduction System / physiopathology
Myocardial Infarction / pathology,  physiopathology*
Myocardium / pathology
Pericardium / physiopathology
Reaction Time / physiology
Refractory Period, Electrophysiological / physiology
Tachycardia, Ventricular / physiopathology*
Ventricular Fibrillation / physiopathology*
Ventricular Function / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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