Document Detail

Electrophysiologic and antiarrhythmic effects of magnesium in patients with inducible ventricular tachyarrhythmia.
MedLine Citation:
PMID:  1551265     Owner:  NLM     Status:  MEDLINE    
Intravenous magnesium is reported to be effective in the treatment of ventricular arrhythmias associated with hypomagnesemia, digitalis toxicity, or prolongation of the QT interval. In most previous reports, magnesium was added to conventional antiarrhythmic drugs that had failed. There are few data on the antiarrhythmic efficacy of magnesium as monotherapy in patients without these associated abnormalities. Ten patients with life-threatening ventricular arrhythmia and inducible ventricular tachyarrhythmia by programmed electrophysiologic testing were treated with intravenous magnesium. Following magnesium infusion, all patients still had inducible ventricular tachyarrhythmia. Moreover, magnesium therapy was not associated with significant changes in ventricular refractory period or in the morphology, cycle length, or hemodynamic response to induced ventricular tachycardia. These data suggest that intravenous magnesium has no significant electrophysiologic or antiarrhythmic effects in patients with life-threatening ventricular arrhythmia and inducible ventricular tachyarrhythmia.
T C Hilton; C Fredman; D J Holt; P Bjerregaard; G H Ira; D L Janosik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  15     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  IM    
Department of Internal Medicine, St. Louis University Medical Center, Missouri.
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MeSH Terms
Heart Conduction System / drug effects*
Magnesium Sulfate / pharmacology*,  therapeutic use
Middle Aged
Tachycardia / drug therapy*,  physiopathology
Ventricular Fibrillation / drug therapy*,  physiopathology
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

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