| Electrophysiologic and antiarrhythmic effects of magnesium in patients with inducible ventricular tachyarrhythmia. | |
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MedLine Citation:
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PMID: 1551265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous magnesium is reported to be effective in the treatment of ventricular arrhythmias associated with hypomagnesemia, digitalis toxicity, or prolongation of the QT interval. In most previous reports, magnesium was added to conventional antiarrhythmic drugs that had failed. There are few data on the antiarrhythmic efficacy of magnesium as monotherapy in patients without these associated abnormalities. Ten patients with life-threatening ventricular arrhythmia and inducible ventricular tachyarrhythmia by programmed electrophysiologic testing were treated with intravenous magnesium. Following magnesium infusion, all patients still had inducible ventricular tachyarrhythmia. Moreover, magnesium therapy was not associated with significant changes in ventricular refractory period or in the morphology, cycle length, or hemodynamic response to induced ventricular tachycardia. These data suggest that intravenous magnesium has no significant electrophysiologic or antiarrhythmic effects in patients with life-threatening ventricular arrhythmia and inducible ventricular tachyarrhythmia. |
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Authors:
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T C Hilton; C Fredman; D J Holt; P Bjerregaard; G H Ira; D L Janosik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 15 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 176-80 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, St. Louis University Medical Center, Missouri. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Electrophysiology Heart Conduction System / drug effects* Humans Magnesium Sulfate / pharmacology*, therapeutic use Male Middle Aged Tachycardia / drug therapy*, physiopathology Ventricular Fibrillation / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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