Document Detail

Electrophoretic and chromatographic patterns of glycosaminoglycans of the umbilical cord vessels and their alteration in EPH-gestosis.
MedLine Citation:
PMID:  9918508     Owner:  NLM     Status:  MEDLINE    
It was found that hyaluronic acid is the most abundant glycosaminoglycan (GAG) both in the umbilical cord arteries and in the umbilical cord veins. Chromatographic and as well as electrophoretic studies demonstrated that EPH-gestosis (Edema-Proteinuria-Hypertension), the most common pathological syndrome occurring in pregnancy, is accompanied by premature replacement of hyaluronic acid by sulphated GAGs in the investigated arteries but not in the veins. Such a replacement is a characteristic feature of the ageing process. One may conclude that EPH-gestosis is associated with a "premature ageing" of the umbilical cord arterial walls. The mechanism and possible role of this phenomenon in pathology are discussed.
L Romanowicz; E Bańkowski; S Jaworski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  45     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-24     Completed Date:  1999-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  805-9     Citation Subset:  IM    
Department of Biochemistry, Medical Academy of Białystok, Poland.
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MeSH Terms
Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Glycosaminoglycans / metabolism*
Muscle, Smooth, Vascular / metabolism,  pathology
Pre-Eclampsia / metabolism*
Umbilical Arteries / metabolism*,  pathology
Umbilical Veins / metabolism*,  pathology
Reg. No./Substance:

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