Document Detail


Electrophiles in foods: the current status of isothiocyanates and their chemical biology.
MedLine Citation:
PMID:  20139631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unlike many classical signals and hormones, exposure of the cells to electrophilic molecules potentially induces a series of characteristic and wide-ranging biological responses by covalently attaching with macromolecules such as proteins as well as small cellular reductants. In addition to chemicals originated from xenobiotics or lipid peroxidation, electrophiles in foods have recently attracted much attention. These compounds have recently been found to induce expression of cytoprotective proteins that are involved in the elimination or inactivation of oxidative stress and carcinogenic electrophiles implicated in several pathogeneses. The redox-sensitive regulating systems such as Keap1/Nrf2/ARE play a key role in this induction and thus are considered to be the most important target of electrophiles in foods. This review highlights the food-derived electrophiles as promising protectors against various diseases, with an emphasis on possible molecular mechanisms. Current knowledge of isothiocyanates (ITCs), representative electrophile compounds from cruciferous vegetables, is discussed also, with consideration of the chemistry, metabolism, absorption, and factors influencing the biological activities of ITCs. In addition, this review attempts to provide a balanced perspective on the relative beneficial and harmful effects of the food electrophiles.
Authors:
Yoshimasa Nakamura; Noriyuki Miyoshi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  74     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-05-20     Revised Date:  2010-05-26    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  242-55     Citation Subset:  IM    
Affiliation:
Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University, Japan. yossan@cc.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport / genetics
Food*
Humans
Isothiocyanates / pharmacology*
Neoplasms / genetics
Oxidation-Reduction
Oxidative Stress
Signal Transduction
Xenobiotics / metabolism
Chemical
Reg. No./Substance:
0/Isothiocyanates; 0/Xenobiotics

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