| Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion. | |
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MedLine Citation:
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PMID: 8547205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial infarction was produced in 27 anesthetized dogs by ligating the left anterior descending (LAD) coronary artery proximal to the septal branch. Nineteen of these animals survived the operation and were studied by programmed stimulation in a random sequence between the third and seventh days after the infarct. Complete electrophysiologic testing was implemented in each animal prior to and after single doses of either alinidine (1 mg/kg IV) or zatebradine (0.5 mg/kg IV). Alinidine prevented reinduction of sustained ventricular tachycardia (SVT) in only 2 of 9 dogs and zatebradine in 1 of 8 dogs. The SVT cycle length was not significantly changed in all cases in which it was still inducible despite drug administration (p > 0.05). Alinidine lengthened the effective refractory period (ERP) in the AV node (p < 0.01), whereas zatebradine did not induce a statistically significant prolongation. Conversely, zatebradine increased the left ventricular ERP, while alinidine left it almost unchanged. The rate-corrected QT interval (QTc) did not significantly differ from control values after the administration of either agents. Also, the duration and the ERP of infarctzone potentials, defined as late potentials, remained unaltered. The results indicate that the bradycardic agents alinidine and zatebradine do not exert antiarrhythmic efficacy against SVT induced during subacute myocardial infarction in conscious dogs. None of these drugs substantially changed ventricular electrophysiology or showed a drug-specific proarrhythmic effect. |
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Authors:
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I Aidonidis; J Brachmann; I Rizos; A Zacharoulis; I Stavridis; P Toutouzas; W Kübler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 9 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-02-22 Completed Date: 1996-02-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 555-63 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / pharmacology* Arrhythmias, Cardiac / physiopathology* Benzazepines / pharmacology* Blood Pressure / drug effects Cardiotonic Agents / pharmacology* Clonidine / analogs & derivatives*, pharmacology Coronary Vessels / physiology* Dogs Electric Stimulation Electrocardiography / drug effects Electrophysiology Evoked Potentials / drug effects, physiology Female Male Myocardial Infarction / chemically induced, physiopathology Refractory Period, Electrophysiological / drug effects Tachycardia, Ventricular / chemically induced, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Benzazepines; 0/Cardiotonic Agents; 33178-86-8/alinidine; 4205-90-7/Clonidine; 85175-67-3/zatebradine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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