Document Detail

Electronmicroscopic autoradiographic study of the distribution of 3H-diltiazem in myocardial cells.
MedLine Citation:
PMID:  4087374     Owner:  NLM     Status:  MEDLINE    
The distribution of 3H-diltiazem in myocardial cell organelles was studied using an electronmicroscopic autoradiographic technique. At 3, 5 and 10 min after 3H-diltiazem injection, silver grains, which indicate the existence of diltiazem, were detected in plasma membranes and intracellular organelles. Silver grains in T systems were observed more frequently at 3 min than at 5 and 10 min. In contrast, silver grains in sarcoplasmic reticula and mitochondria apparently increased with the passage of time. These findings suggest that diltiazem is transported through the T system and may accumulate within the sarcoplasmic reticula and mitochondria. Furthermore, our study revealed morphologically for the first time that the intracellular sites of action where diltiazem was directed were possibly the mitochondria.
M Tagami; Y Nara; A Kubota; T Sunaga; H Maezawa; R Horie; Y Yamori
Related Documents :
8578194 - Somatostatin attenuates the hyperdynamic circulatory state in the gastric mucosa of rat...
525414 - Portal pressure correlated to visceral circulation times.
2384124 - Effects of acute portal hypertension by portal venous stenosis on systemic hemodynamics...
1765244 - Prediction of the recurrence of esophageal varices based on portal vein pressure and ox...
6727724 - An on-line method for evaluation of the in vitro pulsatile pressure drop and regurgitat...
17320504 - Timescales of genetic and epigenetic inheritance.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  26     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-03-04     Completed Date:  1986-03-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  823-32     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Benzazepines / metabolism*
Cell Nucleus / metabolism
Cytoplasm / metabolism
Diltiazem / metabolism*
Microscopy, Electron
Myocardium / metabolism*,  ultrastructure
Time Factors
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of nicardipine on ischemic mechanical failure and tissue injury in isolated perfused rat hea...
Next Document:  Carnitine derivatives in hereditary cardiomyopathic animals.