Document Detail


Electronmicroscopic autoradiographic study of the distribution of 3H-diltiazem in myocardial cells.
MedLine Citation:
PMID:  4087374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of 3H-diltiazem in myocardial cell organelles was studied using an electronmicroscopic autoradiographic technique. At 3, 5 and 10 min after 3H-diltiazem injection, silver grains, which indicate the existence of diltiazem, were detected in plasma membranes and intracellular organelles. Silver grains in T systems were observed more frequently at 3 min than at 5 and 10 min. In contrast, silver grains in sarcoplasmic reticula and mitochondria apparently increased with the passage of time. These findings suggest that diltiazem is transported through the T system and may accumulate within the sarcoplasmic reticula and mitochondria. Furthermore, our study revealed morphologically for the first time that the intracellular sites of action where diltiazem was directed were possibly the mitochondria.
Authors:
M Tagami; Y Nara; A Kubota; T Sunaga; H Maezawa; R Horie; Y Yamori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  26     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-03-04     Completed Date:  1986-03-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  823-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Benzazepines / metabolism*
Cell Nucleus / metabolism
Cytoplasm / metabolism
Diltiazem / metabolism*
Male
Microscopy, Electron
Myocardium / metabolism*,  ultrastructure
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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