Document Detail

Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy.
MedLine Citation:
PMID:  17912565     Owner:  NLM     Status:  MEDLINE    
Topiramate is known to cause ocular side effects such as refractive changes and angle closure. We describe a patient with an electronegative electroretinogram (ERG) which may have been related to topiramate use. Electronegative ERG's have been associated with other drugs in humans as well as topiramate use in rabbits. However, this would be the first suggestion of causality in humans.
Irena Tsui; Daniel Casper; Chai Lin Chou; Stephen H Tsang
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-10-03
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  116     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-04-01     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / adverse effects*
Electroretinography / drug effects*
Fructose / adverse effects,  analogs & derivatives*
Macular Degeneration / chemically induced*,  diagnosis
Myoclonic Epilepsy, Juvenile / drug therapy
Retina / drug effects*,  pathology
Grant Support
R01 EY018213/EY/NEI NIH HHS; R01 EY018213-01A2/EY/NEI NIH HHS
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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