Document Detail

Electron microscopy of hypertensive pulmonary vascular disease.
MedLine Citation:
PMID:  6860554     Owner:  NLM     Status:  MEDLINE    
Hypertensive pulmonary vascular disease secondary to chronic alveolar hypoxia is the result of vasoconstriction and then muscularization of the terminal portions of the pulmonary arterial tree. Ultrastructurally these two phases are characterized respectively by muscular evaginations and the hyperplasia of smooth muscle cells. Plexogenic pulmonary arteriopathy secondary to congenital cardiac shunts, primary pulmonary hypertension or rare cases of cirrhosis of the liver are characterized by concentric-laminar proliferation of myofibroblasts. Later there is a development of plexiform lesions which consist of vascular channels separated by a matrix of proteoglycan containing fibrillary cells and myofibroblasts. Fibrinoid necrosis results from the passage of fibrinogen from the vascular lumen into the arterial wall.
D Heath; P Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of diseases of the chest     Volume:  77     ISSN:  0007-0971     ISO Abbreviation:  Br J Dis Chest     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7511123     Medline TA:  Br J Dis Chest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
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MeSH Terms
Arteries / ultrastructure
Hypertension, Pulmonary / etiology,  pathology*
Lung / blood supply*
Microscopy, Electron
Middle Aged
Muscle, Smooth, Vascular / ultrastructure
Rats, Inbred Strains
Veins / ultrastructure

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