Document Detail

Electron microscopy of the effects of Unguentum lymphaticum on acute experimental lymphedema and various high-protein edemas.
MedLine Citation:
PMID:  6664118     Owner:  NLM     Status:  MEDLINE    
Rats' legs and feet were studied by qualitative and quantitative electron microscopy, including mass densitometry of protein in the tissues and in the initial lymphatics. The tissues were either normal, or had been made edematous by lymphostasis, moderate burns, or dextran. It was found that Unguentum lymphaticum very greatly reduced the amount of edema in the legs with lymphostasis. Since the concentrations of plasma protein in the tissues and initial lymphatics, and its total amounts in the tissues were all greatly reduced, it appears that the cream's anti-lymphedematous activity is via a removal of the excess protein. Since the macrophages were greatly increased in number by the cream (and previous work shows that selectively poisoning these cells prevents much of the cream's effectiveness in lymphedema), very probably it is this increase in their numbers (and possibly their individual proteolytic activities) which is how the cream causes the removal of the excess protein--via an increased proteolysis. The cream also causes an increase in the amount of edema in the rat-foot (after all the injuries, including lymphedema); however the concentration and amount of protein in the tissues is reduced. This is consistent with an inflow of low protein fluid, caused by a vaso-dilatation of the blood microcirculation of this rather specialized tissue. All of these characteristics are very similar to those of many of the benzo-pyrone group of drugs.
J R Casley-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lymphology     Volume:  16     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-22     Completed Date:  1984-03-22     Revised Date:  2006-11-03    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  233-42     Citation Subset:  IM    
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MeSH Terms
Coumarins / pharmacology
Edema / drug therapy*,  pathology
Lymphedema / drug therapy*,  pathology
Macrophages / drug effects
Microscopy, Electron
Plant Extracts / therapeutic use*
Proteins / analysis
Reg. No./Substance:
0/Coumarins; 0/Ointments; 0/Plant Extracts; 0/Proteins; 0/unguentum lymphaticum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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