Document Detail

Electron microscopy of Plasmodium vivax exoerythrocytic schizonts grown in vitro in a hepatoma cell line.
MedLine Citation:
PMID:  3010750     Owner:  NLM     Status:  MEDLINE    
Human hepatoma cells (HepG2-A16) have been shown to be useful for the growth of the exoerythrocytic stages of P. vivax. In order to determine whether the parasites grown in these cells are morphologically similar to those grown in vivo, we performed electron microscopy on the exoerythrocytic (EE) schizonts of P. vivax developed from sporozoites. This study showed for the first time that P. vivax EE schizonts within these cells closely resemble other plasmodial EE schizonts both in vivo and in vitro.
S Uni; M Aikawa; W E Collins; C C Campbell; M R Hollingdale
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  34     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-06-18     Completed Date:  1986-06-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1017-21     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma, Hepatocellular
Cell Line
Cell Membrane / ultrastructure
Cell Nucleus / ultrastructure
Cytoplasmic Granules / ultrastructure
Intracellular Membranes / ultrastructure
Liver Neoplasms
Microscopy, Electron
Mitochondria / ultrastructure
Plasmodium vivax / growth & development,  ultrastructure*
Vacuoles / ultrastructure
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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