Document Detail

Electron microscopic study on the interaction between normal guinea pig peritoneal macrophages and Coxiella burnetii.
MedLine Citation:
PMID:  825466     Owner:  NLM     Status:  MEDLINE    
An electron microscopic study was conducted to explore the interaction between normal guinea pig peritoneal macrophages and phase I and II Coxeilla burnetii previously treated with either normal or immune serum. A comparison was made on the efficiency of phagocytosis and subsequent killing of rickettsiae by macrophages. Both phases of rickettsiae previously treated with normal serum multiplied within phagosomes after phagocytosis with resultant destruction of macrophages. In contrast, suspending rickettsiae in immune serum rendered them more susceptible to phagocytosis and potentiated their destruction within macrophages.
R A Kishimoto; B J Veltri; P G Canonico; F G Shirey; J S Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  14     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-28     Completed Date:  1977-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1087-96     Citation Subset:  IM    
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MeSH Terms
Coxiella / ultrastructure*
Guinea Pigs
Lysosomes / enzymology
Macrophages / microbiology,  ultrastructure*
Microscopy, Electron
Rickettsia typhi / ultrastructure

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