| Electron microscopic investigation of the lens capsule and conjunctival tissues in individuals with clinically unilateral pseudoexfoliation syndrome. | |
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MedLine Citation:
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PMID: 17698197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the presence of pseudoexfoliative material in the unaffected eyes of patients with clinically unilateral pseudoexfoliation syndrome. DESIGN: Prospective observational case series. PARTICIPANTS: Thirty-two consecutive patients with clinically unilateral pseudoexfoliation syndrome, undergoing routine cataract surgery. METHODS: Transmission electron microscopy (TEM) was used to examine conjunctival and anterior lens capsule specimens in affected and unaffected eyes. MAIN OUTCOME MEASURE: Presence of characteristic pseudoexfoliation syndrome findings on TEM. RESULTS: Transmission electron microscopy demonstrated pseudoexfoliative material on either the anterior capsule or conjunctival sample from the clinically unaffected eye in 26 of the 32 patients with clinically unilateral pseudoexfoliation syndrome (81%; 95% confidence interval, 64%-93%). CONCLUSION: The results suggest that the seemingly uninvolved eye in a patient with clinically unilateral pseudoexfoliation syndrome has an 81% likelihood of being affected ultrastructurally. Several population studies examining conversion rates from unilateral to bilateral disease have found a similar proportion of patients with bilateral pseudoexfoliation syndrome in the later decades of life. |
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Authors:
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Parag Parekh; W Richard Green; Walter J Stark; Esen Karamursel Akpek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-15 |
Journal Detail:
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Title: Ophthalmology Volume: 115 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-04 Completed Date: 2008-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 614-619.e2 Citation Subset: IM |
Affiliation:
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Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-9238, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Conjunctiva / pathology* Exfoliation Syndrome / pathology* Female Humans Lens Capsule, Crystalline / pathology* Male Microscopy, Electron Middle Aged Prospective Studies |
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