Document Detail

Electromotive administration of guanethidine for treatment of reflex sympathetic dystrophy: a pilot study in eight patients.
MedLine Citation:
PMID:  8169459     Owner:  NLM     Status:  MEDLINE    
Persistent neuropathic pain is associated with diagnostic and therapeutic challenges that may be very difficult to resolve. This report describes eight patients with incapacitating, posttraumatic neuropathic pain characteristic of reflex sympathetic dystrophy (RSD) who were treated by electromotive administration of guanethidine into affected areas of skin. Following 1-5 treatments, six patients experienced complete resolution of all superficial symptoms of hyperalgesia, pain, pallor, coolness, and sweating of the affected areas. One patient demonstrated partial relief of these symptoms, and one patient failed to respond. The results of this preliminary study suggest that electromotive administration of the the sympatholytic agent, guanethidine, may be useful in the treatment of some types of neuropathic pain. These findings justify the implementation of further controlled studies.
C Bonezzi; D Miotti; R Bettaglio; R Stephen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  9     ISSN:  0885-3924     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2006-08-15    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Department of Anesthesia and Pain Therapy, Fondazione Clinica del Lavoro IRCCS, Pavia, Italy.
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MeSH Terms
Electronics, Medical
Guanethidine / administration & dosage*,  therapeutic use
Injections, Subcutaneous
Middle Aged
Pain, Intractable / drug therapy*
Pilot Projects
Reflex Sympathetic Dystrophy / drug therapy*,  physiopathology*
Reg. No./Substance:

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