| Electromagnetic Detection and Real-time DMLC Adaptation to Target Rotation during Radiotherapy. | |
| | |
MedLine Citation:
|
PMID: 22014957 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: Intrafraction rotation of more than 45° and 25° has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. MATERIALS/METHODS: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3% γ-test. RESULTS: Geometrically, the beam-target rotational alignment difference was 0.3° ± 0.6° for fixed rotation and 0.3° ± 1.3° for active rotation. Dosimetrically, the average failure rate for the γ-test for a fixed rotated target was 11% with tracking and 36% without tracking. The average failure rate for an actively rotating target was 9% with tracking and 35% without tracking. CONCLUSIONS: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1°. Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking. |
| | |
Authors:
|
Junqing Wu; Dan Ruan; Byungchul Cho; Amit Sawant; Jay Petersen; Laurence J Newell; Herbert Cattell; Paul J Keall |
Related Documents
:
|
18987737 - Prospects for detecting supersymmetric dark matter in the galactic halo. 15144017 - Conclusions from two model concepts on germinal center dynamics and morphology. 22092707 - Seasonal patterns in the sunlight sensitivity of bacterioplankton from mediterranean su... 19873327 - The regeneration of visual purple in the living animal. 6514517 - What does the occluding contour tell us about solid shape? 3580407 - Vertical disparity nulling in random-dot stereograms. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-17 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Radiation Oncology, Stanford University, Stanford, CA; School of Health Sciences, Purdue University, West Lafayette, IN. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improving Positioning in High-Dose Radiotherapy for Prostate Cancer: Safety and Visibility of Freque...
Next Document: Metabolic Response on Posttherapy FDG-PET Predicts Patterns of Failure After Radiotherapy for Cervic...