Document Detail


Electrolytes, water, RNA, total creatine and calculated resting membrane potential in muscle tissue from pregnant women.
MedLine Citation:
PMID:  11111128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The nutritional situation of the fetus and pregnant woman is important for human health, but knowledge of how nutrition affects maternal metabolism and physiology during pregnancy is limited. Such knowledge is important, for example in body composition studies, when information about lean tissue composition is needed. Muscle, a main part of lean tissue, changes its composition in response to age and sex, but the effect of pregnancy on this composition is unknown. METHODS: Muscle samples from 11 pregnant and 16 nonpregnant women were analyzed for water, electrolytes, total creatine, alkali-soluble protein (ASP), DNA and RNA. Plasma was analyzed for electrolytes. The amount of extracellular and intracellular water as well as the resting membrane potential (RMP) in muscle were calculated. RESULTS: Pregnant women had lower plasma concentrations of potassium and sodium but higher muscle concentrations of sodium and water (total and extracellular) than nonpregnant women. RMP was more negative in pregnant than in nonpregnant women. Total creatine in muscle (per kilogram ASP) was increased during pregnancy. The muscle content of RNA (per kilogram DNA) was lower in gestational week 18 than in nonpregnant controls. CONCLUSION: Pregnancy influences muscle composition in several ways that are relevant for an increased understanding of interactions between nutrition and reproduction.
Authors:
E Forsum; A M Forsberg; E Nilsson; J Bergström; E Hultman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  44     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-03     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Affiliation:
Division of Nutrition, Department of Biomedicine and Surgery, University of Linköping, University Hospital, Linköping, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Composition*
Body Water
Creatine / analysis
Electrolytes / analysis
Female
Humans
Membrane Potentials
Muscle, Skeletal / chemistry,  physiology*
Nutritional Status
Potassium / analysis
Pregnancy / physiology*
RNA / analysis
Sodium / analysis
Chemical
Reg. No./Substance:
0/Electrolytes; 57-00-1/Creatine; 63231-63-0/RNA; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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