Document Detail

Electrolyte excretion and sodium intake.
MedLine Citation:
PMID:  8141147     Owner:  NLM     Status:  MEDLINE    
Established essential hypertension is characterized by normal equilibrium between the intake and renal excretion of sodium. Urinary sodium excretion is interrelated with that of other ions, such as potassium and calcium, and that the response of blood pressure to salt ingestion can be conditioned by the simultaneous intake of varying levels of those ions. The authors address three aspects: the correlations between urinary excretion of sodium and calcium and sodium and potassium in a population of untreated essential hypertensive persons, the response of blood pressure during the escape induced by exogenous mineralocorticoid administration in mild essential hypertension, and the effect of intravenous calcium gluconate infusion on sodium excretion and renal function. The first part shows that sodium excretion is closely correlated with that of other ions in essential hypertension, and the second part shows that, to escape from the sodium-retaining effect of a mineralocorticoid, mild hypertensive subjects must have increased blood pressure within or near the cutoff point that defines salt sensitivity. Of interest, the elevation in blood pressure takes place while sympathetic nervous activity is blunted. The third part provides evidence to explain one of the mechanisms by which calcium influences renal function and enhances renal sodium excretion. The intrarenal effects of low doses of calcium are dependent on the renal production of prostaglandins.
L M Ruilope; V Lahera; A Araque; C Suarez; J L Rodicio; J C Romero
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  307 Suppl 1     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-28     Completed Date:  1994-04-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S107-11     Citation Subset:  AIM; IM    
Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain.
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MeSH Terms
Atrial Natriuretic Factor / biosynthesis
Blood Pressure / drug effects
Calcium / pharmacology
Electrolytes / urine*
Hypertension / urine*
Kidney / drug effects,  physiology
Mineralocorticoids / pharmacology
Sodium, Dietary / administration & dosage*
Reg. No./Substance:
0/Electrolytes; 0/Mineralocorticoids; 0/Sodium, Dietary; 7440-70-2/Calcium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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