Document Detail


Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy.
MedLine Citation:
PMID:  21447810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrographic seizures are common in neonates with hypoxic-ischemic encephalopathy, but detailed data are not available regarding seizure incidence during therapeutic hypothermia. The objective of this prospective study was to determine the incidence and timing of electrographic seizures in term neonates undergoing whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy as detected by conventional full-array electroencephalography for 72 hours of therapeutic hypothermia and 24 hours of normothermia. Clinical and electroencephalography data were collected from 26 consecutive neonates. Electroencephalograms were reviewed by 2 pediatric neurophysiologists. Electrographic seizures occurred in 17 of 26 (65%) patients. Seizures were entirely nonconvulsive in 8 of 17 (47%), status epilepticus occurred in 4 of 17 (23%), and seizure onset was in the first 48 hours in 13 of 17 (76%) patients. Electrographic seizures were common, were often nonconvulsive, and had onset over a broad range of times in the first days of life.
Authors:
Courtney J Wusthoff; Dennis J Dlugos; Ana Gutierrez-Colina; Anne Wang; Noah Cook; Maureen Donnelly; Robert Clancy; Nicholas S Abend
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-29
Journal Detail:
Title:  Journal of child neurology     Volume:  26     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-25     Completed Date:  2011-09-19     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  724-8     Citation Subset:  IM    
Affiliation:
Division of Clinical Sciences, Imperial College London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Diffusion Magnetic Resonance Imaging
Electroencephalography
Female
Humans
Hypothermia, Induced / methods*
Hypoxia-Ischemia, Brain / complications*,  therapy
Infant, Newborn
Magnetic Resonance Imaging
Male
Prospective Studies
Retrospective Studies
Seizures / diagnosis,  etiology*,  therapy*
Grant Support
ID/Acronym/Agency:
K12 NS049453-07/NS/NINDS NIH HHS; K23 NS076550/NS/NINDS NIH HHS; NS049453/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Loss of Rho GDI? and resistance to tamoxifen via effects on estrogen receptor ?.
Next Document:  Neuronal Ceroid Lipofuscinosis in Qatar: Report of a Novel Mutation in Ceroid-Lipofuscinosis, Neuron...