Document Detail

Electroencephalographic findings with low-dose clozapine treatment in psychotic Parkinsonian patients.
MedLine Citation:
PMID:  8867521     Owner:  NLM     Status:  MEDLINE    
Twenty patients with Parkinson's disease (PD), who developed delusions and psychotic behavior, underwent electroencephalogram (EEG) recordings before and during treatment with low-dose clozapine. Resolution of the psychotic features was observed in all cases. The EEG was unaltered in 15, whereas five patients exhibited increased generalized or focal slowing when compared with the pretreatment tracings. These findings contrast with the high incidence of EEG abnormalities, including epileptiform activity, which are observed when larger doses of clozapine are used in schizophrenic patients, but they underscore that even in low doses, clozapine may cause EEG changes.
M Y Neufeld; J M Rabey; E Orlov; A D Korczyn
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  19     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-15     Completed Date:  1996-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Neurology, Tel-Aviv Elias Sourasky Medical Center, Israel.
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MeSH Terms
Aged, 80 and over
Antipsychotic Agents / administration & dosage,  adverse effects*,  therapeutic use
Clozapine / administration & dosage,  adverse effects*,  therapeutic use
Electroencephalography / drug effects*
Middle Aged
Parkinson Disease / complications,  physiopathology*
Psychotic Disorders / complications,  drug therapy,  physiopathology*
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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