| Electroencephalographic correlates of marihuana-induced euphoria. | |
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MedLine Citation:
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PMID: 7758402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to determine if there is a neurophysiological correlate of marihuana-induced good effects or euphoria. Three groups of 6 male occasional marihuana smokers were prepared for electroencephalographic (EEG) recording and smoked either placebo or marihuana cigarettes containing 1.26% or 2.53% delta 9-tetrahydrocannabinol (delta 9-THC) in a controlled laboratory setting. Using a continuously available non-verbal joystick device and a questionnaire, subjects reported changes in their subjective mood state while EEG activity was continuously recorded. Subjects reported multiple episodes of intense good effects or euphoria during the first 15 min after marihuana. These episodes of euphoria occurred while plasma delta 9-THC levels were rapidly rising. EEG alpha power during these discrete episodes of euphoria was significantly higher suggesting that these transient EEG changes may reflect a neurophysiological correlate of the reinforcing effects of marihuana. |
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Authors:
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S E Lukas; J H Mendelson; R Benedikt |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 37 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-06-26 Completed Date: 1995-06-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: IRELAND |
Other Details:
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Languages: eng Pagination: 131-40 Citation Subset: IM |
Affiliation:
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Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA 02178, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / drug effects, physiology Cerebral Cortex / drug effects, physiopathology Dose-Response Relationship, Drug Electroencephalography / drug effects* Euphoria / drug effects*, physiology Humans Male Marijuana Smoking / physiopathology* Motivation Tetrahydrocannabinol / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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DA 00115/DA/NIDA NIH HHS; DA 02905/DA/NIDA NIH HHS; DA 03994/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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