Document Detail


Electroencephalographic correlates of marihuana-induced euphoria.
MedLine Citation:
PMID:  7758402     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to determine if there is a neurophysiological correlate of marihuana-induced good effects or euphoria. Three groups of 6 male occasional marihuana smokers were prepared for electroencephalographic (EEG) recording and smoked either placebo or marihuana cigarettes containing 1.26% or 2.53% delta 9-tetrahydrocannabinol (delta 9-THC) in a controlled laboratory setting. Using a continuously available non-verbal joystick device and a questionnaire, subjects reported changes in their subjective mood state while EEG activity was continuously recorded. Subjects reported multiple episodes of intense good effects or euphoria during the first 15 min after marihuana. These episodes of euphoria occurred while plasma delta 9-THC levels were rapidly rising. EEG alpha power during these discrete episodes of euphoria was significantly higher suggesting that these transient EEG changes may reflect a neurophysiological correlate of the reinforcing effects of marihuana.
Authors:
S E Lukas; J H Mendelson; R Benedikt
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  37     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  131-40     Citation Subset:  IM    
Affiliation:
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA 02178, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Affect / drug effects,  physiology
Cerebral Cortex / drug effects,  physiopathology
Dose-Response Relationship, Drug
Electroencephalography / drug effects*
Euphoria / drug effects*,  physiology
Humans
Male
Marijuana Smoking / physiopathology*
Motivation
Tetrahydrocannabinol / pharmacokinetics
Grant Support
ID/Acronym/Agency:
DA 00115/DA/NIDA NIH HHS; DA 02905/DA/NIDA NIH HHS; DA 03994/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
1972-08-3/Tetrahydrocannabinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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