Document Detail


Electroencephalographic characterization of scopolamine-induced convulsions in fasted mice after food intake.
MedLine Citation:
PMID:  16890459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to evaluate scopolamine-induced convulsions in fasted mice after food intake effects on the cortical electroencephalogram (EEG). Continuous EEG recordings were taken with Neuroscan for 10 min in freely moving mice with six chronic cortical electrode implants. Animals were weighed and deprived of food for 48 h. EEG recordings were taken at the 24th and 48th hour after their food deprivations. Later, all animals were treated with saline or scopolamine of 3mg/kg i.p. and EEG recordings were repeated for 10 min. Twenty minutes later, they were given food pellets and were allowed to eat ad libitum. All animals were observed for 60 min to determine the incidence and onset of convulsions and EEG recordings were taken simultaneously. The present results demonstrate that food deprivation causes differences in EEG in the elapsed time. The changes in EEG induced after food deprivation become different with scopolamine administration. In scopolamine treatment group, eating caused a series of high-voltage polyspikes and synchronized spikes with a predominant frequency in the 1-3 Hz range and fast activity that represents a typical epileptiform manifestation. It was concluded that the EEG properties and the behavioral patterns of these convulsions are in accordance with each other.
Authors:
Asiye Nurten; Ilknur Ozen; Sacit Karamursel; Ihsan Kara
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Publication Detail:
Type:  Journal Article     Date:  2006-08-04
Journal Detail:
Title:  Seizure : the journal of the British Epilepsy Association     Volume:  15     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-11-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  509-19     Citation Subset:  IM    
Affiliation:
Istanbul University, Institute for Experimental Medical Research, Department of Neuroscience, 34280, Istanbul, Turkey. nurtena@istanbul.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Animals
Electrodes, Implanted
Electroencephalography* / drug effects
Fasting / adverse effects*,  physiology
Male
Mice
Mice, Inbred BALB C
Muscarinic Antagonists / pharmacology*
Scopolamine / pharmacology*
Seizures / chemically induced*,  physiopathology
Chemical
Reg. No./Substance:
0/Muscarinic Antagonists; 51-34-3/Scopolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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