Document Detail

Electroencephalographic and behavioural effects of sodium valproate in patients with photosensitive epilepsy. A single dose trial.
MedLine Citation:
PMID:  6160215     Owner:  NLM     Status:  MEDLINE    
A single oral dose of Sodium valproate (VPA) given as Epilim (10 mg/kg) inhibited photoconvulsive responses, especially to 15--30 Hz frequency flicker, in seven out of ten patients with photosensitive epilepsy. In addition, in all patients (with an exception of one) the amplitude of the secondary slow negative wave of the visual evoked potentials was reduced 4--5 h after drug administration. However, in five of these patients the normalization of electrocortical reactions to a single flash and flickering light was accompanied by somnolence and fatigue, moderate slowing of EEG background, development of 3 Hz spike-wave activity and (in three patients) augmented response to hyperventilation. In two patients the EEG photoconvulsive discharge was exaggerated by VPA. There VPA effects suggest that photosensitivity and the underlying epileptic condition have overlapping albeit different pathophysiology. The data offer no support for the conclusion that reduced photosensitivity produced by VPA is associated with the therapeutic potency of the drug.
M S Myslobodsky; M Mintz; R Douglas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology     Volume:  224     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  111-23     Citation Subset:  IM    
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MeSH Terms
Epilepsy / drug therapy*,  etiology,  physiopathology
Evoked Potentials
Light / adverse effects*
Valproic Acid / therapeutic use*
Reg. No./Substance:
99-66-1/Valproic Acid

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