Document Detail

Electroencephalographic abnormalities in patients with presenile dementia of the Alzheimer type: quantitative analysis at rest and during photic stimulation.
MedLine Citation:
PMID:  9018393     Owner:  NLM     Status:  MEDLINE    
In the present study, quantitative electroencephalographic (EEG) analysis was performed at rest and during photic stimulation (5, 10, and 15 Hz) in nine patients with presenile dementia of the Alzheimer type (AD; mean age at onset, 55 years) and nine sex- and age-matched control subjects. Compared with the normal controls, the AD patients had a significantly lower alpha-2 and beta band power in the resting EEG as well as a significant increase in delta and theta band power. EEG analysis during the photic stimulation demonstrated that the AD patients had a significantly lower EEG power during photic stimulation for the alpha (9.8-10.2 Hz) and beta bands (14.8-15.2 Hz) corresponding to photic stimulation at 10 Hz and 15 Hz, respectively. In addition, when we examined EEG changes from rest to the stimulus condition, the AD patients were found to show significantly smaller changes in EEG power mainly over the posterior regions, irrespective of the stimulus frequency. These findings provide evidence that AD patients have EEG abnormalities in both non-stimulus and stimulus conditions, and suggest diminished EEG reactivity to photic stimulation.
Y Wada; Y Nanbu; Z Y Jiang; Y Koshino; N Yamaguchi; T Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  41     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-02     Completed Date:  1997-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-25     Citation Subset:  IM    
Department of Neuropsychiatry, Kanazawa University, School of Medicine, Japan.
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MeSH Terms
Alzheimer Disease / diagnosis,  physiopathology*,  psychology
Arousal / physiology*
Cerebral Cortex / physiopathology
Diagnosis, Differential
Evoked Potentials, Visual / physiology*
Fourier Analysis
Middle Aged
Photic Stimulation
Signal Processing, Computer-Assisted

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