Document Detail


Electroconvulsive therapy alters dopamine signaling in the striatum of non-human primates.
MedLine Citation:
PMID:  20944554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electroconvulsive therapy (ECT) is one of the most effective therapies for depression and has beneficial motor effects in parkinsonian patients. However, little is known about the mechanisms of therapeutic action of ECT for either condition. The aim of this work was to explore the impact of ECT on dopaminergic function in the striatum of non-human primates. Rhesus monkeys underwent a course of six ECT treatments under a human clinical protocol. Longitudinal effects on the dopaminergic nigrostriatal system were studied over 6 weeks using the in vivo capabilities of positron emission tomography (PET). PET scans were performed prior to the onset of ECT treatments and at 24-48 h, 8-10 days, and 6 weeks after the final ECT treatment. Early increases in dopamine transporter and vesicular monoamine transporter 2 binding returned to baseline levels by 6 weeks post-ECT. Transient increases in D1 receptor binding were also observed, whereas the binding potential to D2 receptors was unaltered. The increase in dopaminergic neurotransmission suggested by our results may account in part for the therapeutic effect of ECT in mood disorders and Parkinson's disease.
Authors:
Anne M Landau; M Mallar Chakravarty; Campbell M Clark; Athanasios P Zis; Doris J Doudet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-13
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  36     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-11-14     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-8     Citation Subset:  IM    
Affiliation:
Aarhus PET Center and Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Striatum / physiology*,  radionuclide imaging
Dopamine / physiology*
Electroconvulsive Therapy / methods*
Macaca mulatta
Male
Neural Pathways / physiology
Positron-Emission Tomography
Synaptic Transmission / physiology
Up-Regulation / physiology
Grant Support
ID/Acronym/Agency:
MOP 74746//Canadian Institutes of Health Research
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