| Electroclinical and imaging findings in ulegyria and epilepsy: a study on 25 patients. | |
| | |
MedLine Citation:
|
PMID: 17682014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Ulegyria refers to cerebral cortex scarring, which results from a perinatal ischaemic brain injury. It presents with a characteristic gyral pattern: small circumvolutions with atrophy at sulci bottom and spared apex. Ulegyria is frequently associated with epilepsy, cerebral palsy and mental disability. We analysed electroclinical and MRI features in patients with ulegyria and epilepsy. PATIENTS AND METHODS: We reviewed 25 patients (14 males/11 females) with ulegyria and epilepsy from the database (about 5000 patients with epilepsy) of our unit. Patients were examined clinically, underwent high resolution MRI, EEG recordings, positron emission tomography, single photon emission computed tomography and neuropsychological testing. Two patients with refractory seizures underwent epilepsy surgery. RESULTS: Mean age of patients was 34 years (5-66) at the reassessment time. The majority (16/25, 64%) had a history of perinatal asphyxia. 15 patients had delayed developmental milestones; 20 had learning disabilities and five patients were severely disabled. Mean age at seizure onset was 4.2 years (1-18). 17 patients (68%) had medically intractable epilepsy. 11 patients (44%) had occipital lobe seizures. The majority (n = 24, 96%) had parieto-occipital lesions on MRI. In 13 patients (52%), ulegyria was bilateral. 12 patients (48%) had hippocampal sclerosis. Two patients underwent epilepsy surgery with an excellent postoperative outcome (Engel class IA and IC). CONCLUSION: Patients with ulegyria often have a history of perinatal asphyxia and present with pharmacoresistant seizures. Their presurgical assessment is complicated because of frequent dual pathology (hippocampal sclerosis) and bilateral lesions. |
| | |
Authors:
|
G Kuchukhidze; I Unterberger; J Dobesberger; N Embacher; G Walser; E Haberlandt; T Gotwald; H Maier; M Ortler; S Felber; G Bauer; E Trinka |
Related Documents
:
|
11879374 - Impaired motor function in patients with psychogenic pseudoseizures. 7324874 - Incidence of primary intracranial neoplasms in an isolated population (the faroese) dur... 14528514 - Duplex sonography of the temporal and occipital artery in the diagnosis of temporal art... 10891904 - Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. 21224774 - The characteristics of gait disturbance and its relationship with posterior tibial soma... 2022144 - Analysis of the colonoscopic findings in patients with rectal bleeding according to the... |
Publication Detail:
|
Type: Journal Article Date: 2007-08-06 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 79 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-04-14 Completed Date: 2008-04-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 547-52 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Asphyxia Neonatorum / complications*, pathology Atrophy Brain Damage, Chronic / diagnosis*, pathology Brain Ischemia / complications*, pathology Cerebral Cortex / pathology* Child Child, Preschool Cicatrix / diagnosis* Echo-Planar Imaging* Electroencephalography* Epilepsies, Partial / diagnosis*, pathology Female Fetal Hypoxia / complications*, pathology Follow-Up Studies Humans Infant Infant, Newborn Magnetic Resonance Imaging* Male Middle Aged Neurologic Examination* Neurons / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
Next Document: Neurological evaluation of patients with Gaucher disease diagnosed as type 1.