Document Detail


Electrochemical-surface enhanced Raman spectroscopy (E-SERS) of uric acid: a potential rapid diagnostic method for early preeclampsia detection.
MedLine Citation:
PMID:  23187309     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An increased level of uric acid in urine and plasma is indicative of the development of preeclampsia, a hypertensive disorder that can occur during pregnancy. The preliminary steps towards developing a rapid tool for early diagnosis of preeclampsia using electrochemical SERS (E-SERS) for the detection of uric acid in urine are presented herein. Characterization of the uric acid species was completed using cyclic voltammetry, UV spectroscopy, Raman spectroscopy and electrochemical surface-enhanced Raman spectroscopy (E-SERS). E-SERS was capable of easily detecting uric acid directly at concentrations <1 mM in urine simulant, without the need for costly enzymes and bulky equipment, and thus demonstrates promise as a rapid point-of-care diagnostic tool for detection of early onset preeclampsia in developing nation settings.
Authors:
Barbara L Goodall; Ashley M Robinson; Christa L Brosseau
Related Documents :
10092839 - Biosynthesis of indole-3-acetic acid in azospirillum brasilense. insights from quantum ...
21917129 - Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vi...
20538459 - Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationsh...
3569649 - Glycerogenic pathway in the rat mammary gland.
6883219 - Effects of inhibitors on early protein, rna, and lipid synthesis in germinating vesicul...
23783279 - Reconstructing a flavodoxin oxidoreductase with early amino acids.
7922889 - Relationship between valine, fatty acids, and spiramycin biosynthesis in streptomyces a...
19150749 - Coupling process between solid-liquid extraction of amino acids by calixarenes and phot...
18363119 - Formic acid: a rare but deadly source of carbon monoxide poisoning.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Physical chemistry chemical physics : PCCP     Volume:  -     ISSN:  1463-9084     ISO Abbreviation:  Phys Chem Chem Phys     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888160     Medline TA:  Phys Chem Chem Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, CanadaB3H 3C3. christa.brosseau@smu.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Subcellular spectroscopic markers, topography and nanomechanics of human lung cancer and breast canc...
Next Document:  Effect of the nanoparticle synthesis method on dendronized iron oxides as MRI contrast agents.