Document Detail


Electrochemical regulation of cell polarity and the cytoskeleton.
MedLine Citation:
PMID:  22736620     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell polarity plays a key role in regulating cell-cell communication, tissue architecture and development. Both internal and external cues participate in directing polarity and feedback onto each other for robust polarization. One poorly appreciated layer of polarity regulation comes from electrochemical signals spatially organized at the level of the cell or the tissue. These signals which include specific ion fluxes, membrane potential gradients or even steady electric fields, emerge from the polarized activation of specific ion transporters, and may guide polarity in wound-healing, development or regeneration. How a given electrochemical cue may influence cytoskeletal elements and cell polarity remains unclear. Here, we review recent progress highlighting the role of electrochemical signals in cell and tissue spatial organization, and elucidating the mechanisms for how such signals may regulate cytoskeletal assembly for cell polarity. © 2012 Wiley-Blackwell.
Authors:
Alexis Campetelli; Daria Bonazzi; Nicolas Minc
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-26
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  -     ISSN:  1949-3592     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Institut Curie, UMR 144 CNRS/IC, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
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