| Electrochemical detection of dopamine in the presence of ascorbic acid using graphene modified electrodes. | |
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MedLine Citation:
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PMID: 20307965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1 mM). The observed linear range for the determination of dopamine concentration was from 4 microM to 100 microM. The detection limit was estimated to be 2.64 microM. |
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Authors:
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Yang-Rae Kim; Sungyool Bong; Yeon-Joo Kang; Yongtak Yang; Rakesh Kumar Mahajan; Jong Seung Kim; Hasuck Kim |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-04 |
Journal Detail:
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Title: Biosensors & bioelectronics Volume: 25 ISSN: 1873-4235 ISO Abbreviation: Biosens Bioelectron Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001289 Medline TA: Biosens Bioelectron Country: England |
Other Details:
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Languages: eng Pagination: 2366-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Chemistry, Seoul National University, Seoul 151-747, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analysis*,
chemistry Biosensing Techniques / instrumentation* Complex Mixtures / analysis, chemistry Conductometry / instrumentation* Dopamine / analysis*, chemistry Electrodes* Equipment Design Equipment Failure Analysis Graphite / chemistry* Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Complex Mixtures; 50-81-7/Ascorbic Acid; 7782-42-5/Graphite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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