Document Detail

Electrochemical behaviors of amino acids at multiwall carbon nanotubes and Cu2O modified carbon paste electrode.
MedLine Citation:
PMID:  18522798     Owner:  NLM     Status:  MEDLINE    
A carbon paste electrode modified with multiwall carbon nanotubes and copper(I) oxide (MWCNT-Cu(2)O CPME) was fabricated, and the electrochemical behaviors of 19 kinds of natural amino acids at this modified electrode were studied. The experimental results showed that the various kinds of amino acids without any derivatization displayed obvious oxidation current responses at the modified electrode. It was also found that the current response values of amino acids were dependent mainly on pH values of buffer solutions. The phenomenon could be explained by the fact that the amino acids suffered complexation or electrocatalytic oxidation processes under different pH values. Six kinds of amino acids (arginine, tryptophan, histidine, threonine, serine, and tyrosine), which performed high-oxidation current responses in alkaline buffers, were selected to be detected simultaneously by capillary zone electrophoresis coupled with amperometric detection (CZE-AD). These amino acids could be perfectly separated within 20 min, and their detection limits were as low as 10(-7) or 10(-8)mol L(-1) magnitude (signal/noise ratio=3). The above results demonstrated that MWCNT-Cu(2)O CPME could be successfully employed as an electrochemical sensor for amino acids with some advantages of convenient preparation, high sensitivity, and good repeatability.
Shuqing Dong; Shan Zhang; Langzhu Chi; Pingang He; Qingjiang Wang; Yuzhi Fang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-17
Journal Detail:
Title:  Analytical biochemistry     Volume:  381     ISSN:  1096-0309     ISO Abbreviation:  Anal. Biochem.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370535     Medline TA:  Anal Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Department of Chemistry, East China Normal University, Shanghai 200062, China.
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MeSH Terms
Amino Acids / analysis*,  chemistry
Biosensing Techniques / methods*
Carbon / chemistry
Copper / chemistry*
Electrophoresis, Capillary / methods
Hydrogen-Ion Concentration
Nanotubes, Carbon / chemistry*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Amino Acids; 0/Nanotubes, Carbon; 1317-39-1/cuprous oxide; 7440-44-0/Carbon; 7440-50-8/Copper

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