Document Detail

Electrochemical Study of Anticancer Drug Daunorubicin at a Water/Oil Interface: Drug Lipophilicity and Quantification.
MedLine Citation:
PMID:  23301839     Owner:  NLM     Status:  Publisher    
In this work, the ion transfer mechanism of anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/1,6-DCH interface, using DPV as quantification technique. Experimental conditions for the analytical determination of DNR were established and a detection limit of 0.80 µM was obtained.
José A Ribeiro; Antonio Fernando Silva; Carlos M Pereira
Related Documents :
12435679 - Therapeutic efficacy of topically applied kp-103 against experimental tinea unguium in ...
8496409 - Mechanisms of action of systemic antifungal agents.
24266589 - Formulation development, in vitro and in vivo evaluation of microemulsion-based gel loa...
24354669 - Oil-cyclodextrin based beads for oral delivery of poorly-soluble drugs.
1929339 - Interactions of amphotericin b and sch 39304 in the treatment of experimental murine ca...
11501989 - Investigational antifungal agents.
6425019 - Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell inject...
25486399 - Polysubstance use is associated with deficits in substance-free reinforcement in colleg...
16945189 - Development and pharmacokinetics of nimodipine-loaded liposomes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optical Probing of Electronic Interaction between Graphene and Hexagonal Boron Nitride.
Next Document:  Control limits for accumulation of plant metabolites: brute force is no substitute for understanding...