Document Detail


Electrochemical Study of Anticancer Drug Daunorubicin at a Water/Oil Interface: Drug Lipophilicity and Quantification.
MedLine Citation:
PMID:  23301839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this work, the ion transfer mechanism of anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) interface and the results obtained were presented in the form of an ionic partition diagram. The partition coefficients of both neutral and ionic forms of the drug were determined. The analytical parameter for the detection of DNR was also investigated in this work. An electrochemical DNR sensor is proposed by means of simple ion transfer at the water/1,6-DCH interface, using DPV as quantification technique. Experimental conditions for the analytical determination of DNR were established and a detection limit of 0.80 µM was obtained.
Authors:
José A Ribeiro; Antonio Fernando Silva; Carlos M Pereira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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