Document Detail

Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes.
MedLine Citation:
PMID:  17386417     Owner:  NLM     Status:  MEDLINE    
A bilayer surface coating, prepared by electrodepositing ruthenium oxide (RuOx) onto a carbon nanotube (CNT) layer, offers dramatic improvements in the stability and sensitivity of voltammetric and amperometric measurements of insulin compared to the individual (CNT or RuOx) coated electrodes. The enhanced electrocatalytic activity towards insulin is indicated from lowering the potential of the oxidation process (starting around 0.35 versus Ag/AgCl) and the substantially higher sensitivity over the entire potential range. A wide linear dynamic range (10-800 nM) was achieved with a detection limit of 1 nM. The marked electrocatalytic activity of the RuOx/CNT coating towards insulin is coupled with a greatly enhanced stability. For example, the insulin amperometric response of the RuOx/CNT-coated electrodes is highly stable, with 97% of the initial activity remaining after 60 min stirring of 2 x 10(-6) M solution (compared to significantly faster current diminutions at the RuOx- or CNT-coated surfaces). The results suggest great promise for miniaturized sensors and detectors for monitoring insulin.
Joseph Wang; Tanin Tangkuaram; Suchera Loyprasert; Terannie Vazquez-Alvarez; Waret Veerasai; Proespichaya Kanatharana; Panote Thavarungkul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-08-07
Journal Detail:
Title:  Analytica chimica acta     Volume:  581     ISSN:  1873-4324     ISO Abbreviation:  Anal. Chim. Acta     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-10     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0370534     Medline TA:  Anal Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Departments of Chemical and Material Engineering, Chemistry and Biochemistry, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5801, USA. <>
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MeSH Terms
Electrochemistry / methods
Insulin / analysis*
Nanotubes, Carbon / analysis*
Oxides / analysis*,  chemistry
Ruthenium Compounds / analysis*,  chemistry
Grant Support
R01 EP 0002189/EP/EPO CDC HHS
Reg. No./Substance:
0/Nanotubes, Carbon; 0/Oxides; 0/Ruthenium Compounds; 11061-68-0/Insulin

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