| Electrocardiography as an early cardiac screening test in children with mitochondrial disease. | |
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MedLine Citation:
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PMID: 21189931 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate myocardial conductivity to understand cardiac involvement in patients with mitochondrial disease. METHODS: We performed retrospective study on fifty-seven nonspecific mitochondrial encephalopathy patients with no clinical cardiac manifestations. The patients were diagnosed with mitochondrial respiratory chain complex defects through biochemical enzyme assays of muscle tissue. We performed standard 12-lead electrocardiography (ECG) on all patients. RESULTS: ECG abnormalities were observed in 30 patients (52.6%). Prolongation of the QTc interval (>440 ms) was seen in 19 patients (33.3%), widening of the corrected QRS interval in 15 (26.3%), and bundle branch block in four (7.0%). Atrioventricular block, premature atrial contraction and premature ventricular contraction were seen in two patients each (3.5%) and Wolff-Parkinson-White syndrome in one patient (1.8%). CONCLUSION: Given this finding, we recommend active screening with ECG in patients with mitochondrial disease even in patients without obvious cardiac manifestation. |
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Authors:
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Ran Baik; Jung Hyun Chae; Young Mock Lee; Hoon Chul Kang; Joon Soo Lee; Heung Dong Kim |
Publication Detail:
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Type: Journal Article Date: 2010-05-31 |
Journal Detail:
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Title: Korean journal of pediatrics Volume: 53 ISSN: 2092-7258 ISO Abbreviation: Korean J Pediatr Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-12-30 Completed Date: 2011-07-14 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101215374 Medline TA: Korean J Pediatr Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 644-7 Citation Subset: - |
Affiliation:
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Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. |
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