Document Detail

Electrocardiographic transmural dispersion of repolarization in patients with inherited short QT syndrome.
MedLine Citation:
PMID:  18713331     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Short QT syndrome (SQTS) carries an increased risk for sudden cardiac death. However, only a short QT interval does not express the risk of ventricular arrhythmias. Thus, additional evaluation of the repolarization abnormality in SQTS patients is essential. In experimental models of SQTS, increased transmural dispersion of repolarization (TDR) and its electrocardiographic counterpart T-wave peak to T-wave end interval (TPE) appeared critical for induction of polymorphic ventricular tachycardia (PMVT). In a clinical study with acquired long QT syndrome patients, TPE/QT ratio > 0.28 indicated arrhythmia risk. We hypothesized that the TPE/QT ratio would be greater in SQTS patients than in control subjects. METHODS AND RESULTS: We compared the behavior of the electrocardiographic TDR in three seriously symptomatic SQTS patients of unknown genotype presenting baseline QTc values < 320 ms and in nine healthy age-matched control subjects. We determined QT and TPE intervals as well as TPE/QT ratio from 24-hour ECG recordings using a computer-assisted program. Diurnal average of TPE/QT ratio was 0.28 +/- 0.03 in SQTS patients and 0.21 +/- 0.02 in control subjects (P = 0.01). SQTS patients had also lesser capacity to change TPE intervals from steady-state conditions to abrupt maximal values than control subjects. CONCLUSION: SQTS patients have increased and autonomically uncontrolled electrocardiographic TDR. According to experimental SQTS models, the present results may in part explain increased vulnerability of SQTS patients to ventricular arrhythmias.
Olli Anttonen; Heikki Väänänen; Juhani Junttila; Heikki V Huikuri; Matti Viitasalo
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  13     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Department of Medicine, Päijät-Häme Central Hospital, Lahti, Finland.
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MeSH Terms
Aged, 80 and over
Arrhythmias, Cardiac / diagnosis*,  genetics*
Case-Control Studies
Electrocardiography / methods*
Electrocardiography, Ambulatory / methods
Electrophysiologic Techniques, Cardiac / methods
Follow-Up Studies
Genetic Predisposition to Disease*
Heart Conduction System / physiopathology*
Middle Aged
Myocardial Contraction / physiology
Risk Assessment
Sampling Studies
Severity of Illness Index
Statistics, Nonparametric
Ventricular Remodeling / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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