| Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial. | |
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MedLine Citation:
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PMID: 15289365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Stratifiers of sudden and total mortality risk are needed to optimally target preventive therapies in patients with coronary artery disease and impaired ventricular function. We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT). METHODS AND RESULTS: We analyzed the ECGs of 1638 patients from MUSTT who did not receive antiarrhythmic therapy (antiarrhythmic medication or implantable cardioverter-defibrillator). After adjustment for other significant factors, left bundle-branch block and intraventricular conduction delay were associated with a 50% increase in the risk of both arrhythmic and total mortality. Right bundle-branch block was not associated with arrhythmic or total mortality. Left ventricular hypertrophy was the only ECG predictor of arrhythmic (hazard ratio, 1.35; 95% CI, 1.08 to 1.69) but not total mortality. CONCLUSIONS: In patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia, QRS prolongation resulting from left bundle-branch block or intraventricular conduction delay but not right bundle-branch block provided prognostic information about the risk of arrhythmic and total mortality independently of electrophysiological evaluation and ejection fraction. Left ventricular hypertrophy was associated with increased arrhythmic but not total mortality. |
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Authors:
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Peter J Zimetbaum; Alfred E Buxton; William Batsford; John D Fisher; Gail E Hafley; Kerry L Lee; Michael F O'Toole; Richard L Page; Matthew Reynolds; Mark E Josephson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial Date: 2004-08-02 |
Journal Detail:
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Title: Circulation Volume: 110 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-17 Completed Date: 2005-02-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 766-9 Citation Subset: AIM; IM |
Affiliation:
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Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, Mass 02215, USA. pzimetba@BIDMC.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / mortality*, physiopathology Bundle-Branch Block / epidemiology, physiopathology Cardiac Pacing, Artificial Cause of Death Electric Stimulation Electrocardiography* Female Heart Arrest / epidemiology, etiology Heart Conduction System / physiopathology* Humans Hypertrophy, Left Ventricular / mortality, physiopathology Male Middle Aged Proportional Hazards Models Risk Single-Blind Method Tachycardia / mortality, physiopathology United States / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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